Surveillance B lymphocytes and mucosal immunoregulation

Organogenic role of B lymphocytes in mucosal immunity.

Follicle-associated epithelium (FAE) in the intestinal Peyer's patches contains M cells that deliver pathogens to organized lymphoid tissue. Development of Peyer's patches, FAE, and M cells was found to be impaired in mice that had no B cells. Transgenic expression of membrane-bound immunoglobulin M restored B cells and FAE development. The lack of M cells abrogated infection with a milk-borne ...

Intestinal Mucosal Lymphocytes

The interaction of mucosal lymphocytes and intestinal epithelial cells is thought to be important in regulating immune response in the intestinal mucosa, but conclusive evidence is limited. Here we demonstrate the expression of IL-7 mRNA in human intestinal mucosa by combined reverse transcription PCR and Southern blot hybridization. Immunohistochemistry and in situ hybridization confirm the pr...

Isolation of Mucosal Lymphocytes

Social Stress and Immunoregulation

Qualified and healthy lifestyle consists of extensivebroad dimensions of physical health, resistance againstdiseases, fast recovery following disease, better socialcommunications, flexibility in facing social problems,better education, better interactions, stress management,transcendental individual and social behavior, as well asmorality. A variety of the contemporary academic studiesand scien...

Immunoregulation of hepatitis B virus infection--rationale and clinical application.

Hepatitis B virus (HBV) is susceptible to the cellular immune responses, especially to the signal of interferon (IFN)-gamma. The action of IFN-gamma is pleiotropic, and causes downregulation of HBV in protein, RNA, and possibly DNA levels. Therefore, therapeutic vaccination to induce cellular immune responses to HBV is a promising approach for controlling chronic HBV infection. A number of clin...